Vitamin B6 Toxicity

(Pyridoxine Toxicity)

ByLarry E. Johnson, MD, PhD, University of Arkansas for Medical Sciences
Reviewed/Revised Aug 2024
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Vitamin B6 toxicity may be caused by ingestion of megadoses (> 500 mg/day) of pyridoxine. Toxicity may cause peripheral neuropathy. Diagnosis is clinical. Recovery is slow and sometimes incomplete.

Sources, Functions, and Effects of Vitamins).

Dietary sources of vitamin B6 include organ meats (eg, liver), whole-grain cereals, fish, and legumes. (See also Overview of Vitamins.)

The ingestion of megadoses (>

Diagnosis of Vitamin B6 Toxicity

  • Clinical evaluation

Diagnosis of vitamin B6 toxicity is clinical.

Treatment of Vitamin B6 Toxicity

Treatment of vitamin B6 toxicity is to stop taking vitamin B6.

Recovery is slow and, for some patients, incomplete.

Drugs Mentioned In This Article
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