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Professional

Special Subjects

Dietary Supplements

Glucosamine

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<div class="para" > Glucosamine is claimed to relieve pain due to osteoarthritis, possibly with both analgesic and disease-modifying effects. Mechanism is unknown. Mechanism for glucosamine sulfate may be related to improved glycosaminoglycan synthesis as a result of the sulfate moiety. Dosage of glucosamine in all its forms is 500 mg orally 3 times a day.</div>

Claims

<div class="para" > Evidence supports use of glucosamine sulfate from Rotta Research Laboratorium for treatment of mild-to-moderate osteoarthritis of the knee when given for at least 6 months ( <a href="/professional/special-subjects/dietary-supplements/glucosamine#v75591597" data-toggle="tooltip" title ="References" data-id="1acb8649-35b3-450e-a0d8-e946c06ae32b" data-itemid="7b7b34cc-5bd9-4133-a396-db21f214899e">2-3</a> <a href="/professional/special-subjects/dietary-supplements/glucosamine#v75591597"> References Glucosamine is a precursor of multiple cartilage constituents. It is extracted from chitin (in shells of crabs, oysters, and shrimp) and is taken in tablet or capsule form, usually as glucosamine... read more </a> ). Other formulations still need to be rigorously evaluated. The role of glucosamine sulfate in the treatment of more severe knee osteoarthritis and osteoarthritis in other locations is less well-defined. </div>

Evidence

<div class="para" > Allergy (in patients who have shellfish allergy and take forms extracted from shellfish), dyspepsia, fatigue, insomnia, headache, photosensitivity, and nail changes may occur. Patients with chronic liver disease should also avoid glucosamine if possible, because of potential hepatotoxicity when taking glucosamine with or without chondroitin ( <a href="/professional/special-subjects/dietary-supplements/glucosamine#v75591597" data-toggle="tooltip" title ="References" data-id="f9940f69-c4d2-4fb4-af9a-5ef92cffad25" data-itemid="7b7b34cc-5bd9-4133-a396-db21f214899e">8</a> <a href="/professional/special-subjects/dietary-supplements/glucosamine#v75591597"> References Glucosamine is a precursor of multiple cartilage constituents. It is extracted from chitin (in shells of crabs, oysters, and shrimp) and is taken in tablet or capsule form, usually as glucosamine... read more </a> ).</div>

Adverse Effects

<div class="para" > High-dose glucosamine may interact with warfarin and result in bruising or bleeding, according to case reports and information submitted to the World Health Organization. No other important drug interactions are known.</div>

Drug Interactions

<div class="para" > 1. <a rel="noopener nofollow" target="_blank" href="http://pubag.nal.usda.gov/pubag/article.xhtml?id=597740">Liu L, Liu Y, Shin HD, et al</a>: Microbial production of glucosamine and N-acetylglucosamine: advances and perspectives. Appl Microbiol Biotechnol 97(14):6149-6158, 2013. doi: 10.1007/s00253-013-4995-6</div>

References

<div class="para" > The following English-language resource may be useful. Please note that THE MANUAL is not responsible for the content of this resource.</div>

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