Aztreonam is the only antibiotic in an antibiotic class called monobactams, which are a subclass of beta-lactam antibiotics (antibiotics that have a chemical structure called a beta-lactam ring). Beta-lactam antibiotics also includecarbapenems, cephalosporins, and penicillins.
Aztreonam is commonly used to treat people who are allergic to some beta-lactam antibiotics and is used in combination with other antibiotics to treat certain antibiotic-resistant bacteria.
Most bacteria have an outer covering (cell wall) that protects them. Like the other beta-lactam antibiotics, aztreonam works by preventing bacteria from forming this cell wall, resulting in death of the bacteria.
Aztreonam
Common Uses | Some Potential Side Effects | Comments |
|---|---|---|
Infections caused by gram-negative bacteria | Injection site discomfort and swelling Diarrhea, nausea, vomiting, or a combination Rash | Can typically be used in people allergic to other beta-lactam antibiotics, such as penicillins, cephalosporins, and carbapenems, but should be avoided in people with severe allergies to ceftazidime or cefiderocol Must be given by injection |
(See also Overview of Antibiotics.)
Use of Aztreonam During Pregnancy and Breastfeeding
Aztreonam should be taken during pregnancy only when the benefits of treatment outweigh the risks. No harmful effects on the fetus have been observed in animal studies, but no well-designed studies have been done in pregnant women. (See alsoSafety of Medications During Pregnancy.)
Use of aztreonam during breastfeeding is generally considered acceptable. (See alsoMedication and Substance Use During Breastfeeding.)
