- Overview of Peripheral Nervous System Disorders
- Disorders of Neuromuscular Transmission
- Isaacs Syndrome
- Stiff-Person Syndrome
- Guillain-Barré Syndrome (GBS)
- Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
- Hereditary Neuropathies
- Hereditary Motor Neuropathy With Liability to Pressure Palsies (HNPP)
- Amyotrophic Lateral Sclerosis (ALS) and Other Motor Neuron Diseases (MNDs)
- Myasthenia Gravis
- Nerve Root Disorders
- Peripheral Neuropathy
- Mononeuropathies
- Multiple Mononeuropathy
- Polyneuropathy
- Brachial Plexus and Lumbosacral Plexus Disorders
- Spinal Muscular Atrophies (SMAs)
- Thoracic Outlet Compression Syndromes (TOS)
Peripheral neuropathy is dysfunction of one or more peripheral nerves (the part of a nerve distal to the root and plexus). It includes numerous syndromes characterized by varying degrees of sensory disturbances, pain, muscle weakness and atrophy, diminished deep tendon reflexes, and vasomotor symptoms, alone or in any combination. Initial classification is based on history and physical examination. Electromyography and nerve conduction studies (electrodiagnostic testing) help localize the lesion and determine whether the pathophysiology is primarily axonal (often metabolic) or demyelinating (often autoimmune). Treatment is aimed mainly at the cause.
(See also Overview of Peripheral Nervous System Disorders.)
Peripheral neuropathy may affect
A single nerve (mononeuropathy)
≥ 2 discrete nerves in separate areas (multiple mononeuropathy)
Many nerves simultaneously suggesting a diffuse process (polyneuropathy)
