Major Causes of Chronic Kidney Disease

Cause

Examples

Chronic tubulointerstitial nephropathies

See table Causes of Chronic Tubulointerstitial Nephritis

Glomerulopathies (primary)

Focal segmental glomerulosclerosis

Idiopathic crescentic glomerulonephritis

IgA nephropathy

Membranoproliferative glomerulonephritis

Membranous nephropathy

Glomerulopathies associated with systemic disease

Amyloidosis

Diabetes mellitus

Antiglomerular basement membrane (GBM) antibody disease (also known as Goodpasture syndrome)

Granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis)

Hemolytic-uremic syndrome

Mixed cryoglobulinemia

Postinfectious glomerulonephritis

Systemic lupus erythematosus

Hereditary nephropathies

Autosomal dominant interstitial kidney disease (medullary cystic kidney disease)

Hereditary nephritis (Alport syndrome)

Nail-patella syndrome

Polycystic kidney disease

Hypertension

Hypertensive nephrosclerosis

Obstructive uropathy

Benign prostatic hyperplasia

Posterior urethral valves

Retroperitoneal fibrosis

Ureteral obstruction (congenital, calculi, cancer)

Vesicoureteral reflux

Renal macrovascular disease (vasculopathy of renal arteries and veins)

Renal artery stenosis caused by atherosclerosis or fibromuscular dysplasia

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