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1). A 2011 systematic review and meta-analysis of 3 studies (1247 subjects) of 10% and 15% Polyphenon E verified efficacy for treatment of external anogenital warts (23).

456), and a different meta-analysis reported favorable cardiovascular outcomes (7

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(See also table Some Possible Dietary Supplement–Drug Interactions.)

1. 1. Stockfleth E, Beti H, Orasan R, et al: Topical Polyphenon E in the treatment of external genital and perianal warts: a randomized controlled trial. Br J Dermatol 158(6):1329-1338, 2008. doi: 10.1111/j.1365-2133.2008.08520.x

2. 2. Tzellos TG, Sardeli C, Lallas A, et al J Eur Acad Dermatol Venereol 25(3):345-353, 2011. doi: 10.1111/j.1468-3083.2010.03796.x

3. 3. Langley PCJ Med Econ 13(1):1-7, 2010. doi: 10.3111/13696990903451461

4. 4. Jurgens TM, Whelan AM, Killian L, et alCochrane Database Syst Rev 12: CD008650, 2012. doi: 10.1002/14651858.CD008650.pub2

5. 5. Filippini T, Malavolti M, Borrelli F, et alCamellia sinensis) for the prevention of cancer. Cochrane Database Syst Rev 3(3):CD005004. doi: 10.1002/14651858.CD005004.pub3

6. 6. Guo Y, Zhi F, Chen P, et alMedicine (Baltimore) 96(13):e6426, 2017. doi: 10.1097/MD.0000000000006426

7. 7. Pang J, Zhang Z, Zheng TZ, et alInt J Cardiol 202:967-974, 2016. doi: 10.1016/j.ijcard.2014.12.176

8. 8. Isomura T, Suzuki S, Origasa H, et alEur J Clin Nutr 70(11):1221-1229, 2016. doi: 10.1038/ejcn.2016.78

9. 9. Oketch-Rabah HA, Roe AL, Rider CV, et alToxicol Rep 7:386-402, 2020. doi:10.1016/j.toxrep.2020.02.008

The following English-language resource may be useful. Please note that THE MANUAL is not responsible for the content of this resource.

1. National Institutes of Health (NIH), National Center for Complementary and Integrative Health: