Valeriana officinalis) root and rhizomes (underground stems) contain its active ingredients, including valepotriates and pungent odiferous oils.
(See also Overview of Dietary Supplements and National Institutes of Health (NIH): Valerian fact sheet for health professionals.)
Claims
Evidence
Adverse Effects
Drug Interactions
9), but no clinical studies have shown any drug metabolism interactions.
(See also table Some Possible Dietary Supplement–Drug Interactions.)
References
1. Bent S, Padula A, Moore D, et al. Am J Med 119(12):1005–1012, 2006. doi: 10.1016/j.amjmed.2006.02.026
2. Fernández-San-Martín MI, Masa-Font R, Palacios-Soler L, et alSleep Med 11(6):505-511, 2010. doi: 10.1016/j.sleep.2009.12.009
3. Taibi D, Landis C, Petry H, et alSleep Med Rev 11(3):209–223, 2007. doi: 10.1016/j.smrv.2007.03.002
4. Taavoni S, Ekbatani N, Kashaniyan M, et alMenopause 18(9):951-955, 2011. doi: 10.1097/gme.0b013e31820e9acf
5. Shinjyo N, Waddell G, Green JJ Evid Based Integr Med 25:2515690X20967323, 2020. doi:10.1177/2515690X20967323
6. Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN, Heald JL: Clinical practice guideline for the tharmacologic treatment of chronic insomnia in adults: an American Academy of Sleep Medicine Clinical Practice Guideline. J Clin Sleep Med 13(2):307-349, 2017. Published 2017 Feb 15. doi:10.5664/jcsm.6470
7. Mirabi P, Mojab FIran J Pharm Res 12(1):217-222, 2013. PMID: 24250592
8. Pakseresht S, Boostani H, Sayyah M J Complement Integr Med 8, 2011. doi: 10.2202/1553-3840.1465
9. Hellum BH, Nilsen OG: In vitro inhibition of CYP3A4 metabolism and P-glycoprotein-mediated transport by trade herbal products. Basic Clin Pharmacol Toxicol 102(5):466-475, 2008. doi: 10.1111/j.1742-7843.2008.00227.x
More Information
The following English-language resource may be useful. Please note that THE MANUAL is not responsible for the content of this resource.
